|
KMID : 0381120200420060609
|
|
Genes and Genomics
2020 Volume.42 No. 6 p.609 ~ p.617
|
|
|
RNA-mediated regulation of chromatin structures
|
|
Kwon Young-Tae
Chung Yun-Doo
|
|
|
Abstract
|
|
|
|
It is now evident that transcriptional gene regulation usually requires the re-organization of chromatin architecture. Increasing evidence suggested various kinds of RNAs are involved in this process. Especially the nascent RNAs retained at their site of transcription can serve as a scaffold for organizing transcriptionally either favorable or unfavorable chromatin structures. An emerging concept of phase separation explains how these chromatin structures can be maintained as physically discrete subcompartments within membrane-less nucleoplasm. Evidences that support the crucial role of nascent RNAs in the formation of phase-separated condensates are now rapidly growing.
|
|
|
KEYWORD
|
|
|
Nascent RNA, Heterochromatin, Chromatin-associated RNA, Transcription hub, Epigenetics, Histone modification, eRNA, 3D genome
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
 
|